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Revotek

ApplicationChengdu, ChinaFounded 2014· One of 686 Application companies tracked by AMPulse

A pioneering regenerative medicine company specializing in biological additive manufacturing, specifically the world's first 3D bioprinted stem cell vascular grafts (REVOVAS) and proprietary 'Biosynsphere' bio-ink technology.

CEO / Founder
Professor Y. James Kang
Team Size
51-200
Stage
Defunct
Total Funding
$41.4M
Latest Round
Corporate Round
Key Investors
Sichuan Languang Development (600466.SH), Chinese State 863 Program (Grants)

Technology & Products

Key Products

REVOVAS®: 3D bioprinted stem cell vascular transplant system, Biosynsphere® (Biological Bricks): Proprietary stem cell-based bio-ink, 3D Bio-vascular Printer: World's first specialized vascular bioprinting hardware, Medical Imaging Cloud Platform: AI-driven modeling system for personalized organ/tissue design, Bio-active Post-printing Treatment System

Technological Advantage

Combines stem cell biology with additive manufacturing and AI cloud modeling to achieve 'organ regeneration' rather than mere mechanical substitution; features a 1700+ day successful follow-up in non-human primate trials, the longest in the industry.

Patent position

Revotek filed 0 patent families in 2022–2024, down from 10 in 2019–2021, a 100% fall, while tracked AM filings in the same patent offices fell 15%, meaning its filing volume fell more sharply. AMPulse analysis

Filing momentum
0 families filed 2022–2024, 10 in 2019–2021 (-100%); all tracked AM filings in the same offices -15%
Filed in
CN 42%US 34%EP 34%WO 26%
Named competitors, AM patent families
Cyfuse Biomedical 3

53 AM patent families in total. Recent years are still being published, so read a filing change against the same-office figure.

Differentiation

Value Proposition

Enables the creation of bio-active, personalized vascular grafts that integrate seamlessly with host tissue (endothelialization), eliminating the need for long-term anticoagulant medication and overcoming the limitations of synthetic or cadaveric grafts.

How They Differentiate

Revotek utilizes a proprietary 'spatial rotating bioprinting platform' and 'Biosynsphere' (stem cell biological bricks) to create living, scaffold-free vascular grafts that integrate and endothelialise within the host, unlike the needle-array (Kenzan) methods or synthetic scaffold approaches used by competitors.

Market & Competition

Target Customers

Patients with end-stage vascular diseases (e.g., Peripheral Arterial Disease - PAD), cardiovascular surgeons, and healthcare institutions requiring regenerative tissue solutions.

Industry Verticals

Regenerative Medicine, Cardiovascular Healthcare, Organ Manufacturing, Pharmaceutical Drug Screening, Biotechnology Research

Competitors

Regenovo Biotechnology (Hangzhou); Cyfuse Biomedical (Japan); Organovo (USA)

Growth & Milestones

Growth Metrics

NHC-backed FIH clinical path started 2022 with West China Hospital, but parent *ST蓝光 cut funding; board approved Revotek business shutdown (关停) Mar 2023 and asset disposal; R&D reported stagnant through 2024 filings. Legal entity still 存续 (subsidiary ~98.9%).

Major Milestones

2015: Launched the world’s first 3D biological vascular printer, 2016: Achieved world's first successful implantation of 3D bioprinted vessels in rhesus monkeys, 2019: Documented survival of implanted vessels reaching over 1000 days in animal models, 2022: Received National Health Commission approval for First-in-Human (FIH) clinical trials, 2024: Featured on CCTV-4 for leadership in clinical regenerative medicine

Notable Customers

West China Hospital of Sichuan University (Strategic Clinical Partner)

https://www.revotek.com.cn

AM patents

AM-relevant patents linked to this company.

Patents
78
Granted
12
Families
53

Leading domains: process (78), equipment (69), application (46)

Filings by year: 2020: 7 · 2019: 5 · 2018: 14 · 2016: 11 · 2015: 41

  1. Bio-printer movement platform and bio-printer105624038 · CN
  2. MANUFACTURING METHOD OF LUMEN TISSUE CONSTRUCT20210268716 · US
  3. COMPOSITIONS FOR CELL-BASED THREE DIMENSIONAL PRINTING03903843 · EP
  4. HEAD ASSEMBLY OF BIOLOGICAL PRINTER AND BIOLOGICAL PRINTER03398756 · EP
  5. Bio-brick for bio-printing and application thereof108126242 · CN

Funding rounds

  • Corporate Round$33.6M2015-10Lead: Sichuan Languang Development · Source: Web
  • Seed$7.8M2014-09Lead: Sichuan Languang Development · Source: Web

Why this company matters

AMPulse analysis, not a company disclosure

Revotek occupies a distinctive position at the intersection of additive manufacturing and regenerative medicine, focusing on scaffold-free bioprinting of living vascular grafts. Unlike synthetic or cadaveric alternatives that require long-term anticoagulant medication, Revotek's approach aims to produce bio-active vessels that endothelialize and integrate fully with the host tissue, potentially eliminating the need for lifelong drug therapy.

The company's core technology centers on its proprietary 'Biosynsphere' bio-ink, which encapsulates stem cells in a nutrient shell. These units are deposited using a spatial rotating bioprinting platform to form functional, living vessels without an external scaffold. The REVOVAS system comprises the bioprinter, the bio-ink, and a post-printing treatment system, supported by an AI-driven medical imaging cloud platform for personalized tissue design.

Revotek's primary target is patients with end-stage vascular diseases such as peripheral arterial disease, with cardiovascular surgeons and healthcare institutions as key customers. The company has a strategic clinical partnership with West China Hospital of Sichuan University and received National Health Commission approval for first-in-human clinical trials in 2022. Preclinical data includes a 1700-plus-day successful follow-up in non-human primate trials, which the company claims is the longest in the industry.

The company competes with Regenovo Biotechnology, Cyfuse Biomedical, and Organovo, differentiating through its scaffold-free, stem-cell-based method versus needle-array or synthetic scaffold approaches. Key risks include the long and uncertain regulatory pathway for bioprinted living implants and the scalability of manufacturing personalized vascular grafts. Revotek has raised approximately $41.4 million from investors including Sichuan Languang Development and Chinese state grants.